I have issues after Windows 10 Updates. Display driver updates can wreak havoc on the old games, but Windows also seems to have a penchant for changing your settings, so check the Properties page of your SH4. You might have to noodle with the High DPI settings if you have a newer display monitor. You should also match your display settings to the "native" resolution of your LCD monitor, and set the game to that same setting. Again, if you have a newer display, you might have to do a multiple of the setting. Also, I do not start the game through UPlay, but use the SH4.exe file directly.
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