Welcome back CapZap!
You’ll have to get Nvidia Inspector (assuming you have Nvidia GC)
In SH3 profile, you’ll have to put Antialiasing compatibility to Diablo III, antialiasing mode to override any application setting, antialiasing to multisampling X4, antialiasing gamma correction to OFF, texture filtering negative LOD bias to clamp, texture filtering to quality (or high quality)
Make sure you have same setting in your Nvidia control panel —-> application/SH3!
If needed, you can even add some anisotropic filter (i don’t)
For the .val & sim files, you open it with S3D application (available somewhere in download section)