No other problems with your computer, software?
I'd rename the SH3 folders, including the one in MyDocuments.
Then reinstall and see if the load happens.
If you don't have saves from before, make sure you are looking in that MyDocuments folder both in and out of your new install. Save a game first, of course.
If the new install works fine, copy the new folder into the old folder and from that folder, try to load. If it fails, you have one or more corrupt game files.
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