How much video RAM do you have? My current rig has 6 GB of video RAM, 16 GB of system RAM. I would suggest your new rig have at least 2 GB of video RAM, as some new mods require at least 2 GB of video RAM. LSH 2015, for example.
The game will run in Windows 10, you just have to be careful to follow the instructions for installation as found in tutorials on this site. The main rule is not to install it in the program files folder, but install it in a custom folder in the root of C:\ so as to bypass the Windows user account stuff.
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