[THEBERBSTER]

Hi MM

C:\Games\Silent Hunter 3\sh3.exe")

Did you mean your path is C:\Games\SilentHunter3\sh3.exe

You need to run Windows 10 in compatibility mode for Windows 7.
Your applications need to be run as administrators.
GWX should be installed in your main game folder.

You also need the 4gb patch
4Gig Patch For SH3 > Already Activated In LSH3-2015

Although you have correctly setup your gpu you in some cases you also need to change:
Override High DPI Scaling Behavior > Pictorial

When you first install the game you need to start the stock game and go into the Naval Academy and then exit so it sets up your SH3 saved games folder.
In Options, Video Settings you can also setup the games graphics for wide screen as the default is 4.3 and you are going to use a 16.9 widescreen mod so "Full Screen" needs to be ticked.