The TWOS notes say to not save the game when AI units or planes are nearby, this can lead to save corruption. Also later when you are in the bunker, do not use autosaves.
If you are in your patrol area, leave the area before saving otherwise your progress in the area is reset when you save inside. (That's not critical however, you just won't get renown points to distribute for your crew, or you must redo the 48 hour patrol in that zone).
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