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A Warm Welcome To The Subsim Community > Nidge2112
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Will I have to start again or will U-play cloud remember crew settings /career.

Not as long as you do not delete your saved games folder > C:\Documents\SH5
You will be given the option to keep your saved games during the uninstall process.

You could also go off line and use your saved games folder rather than taking your saved games also from the cloud which is more reliable.
Post #69 How To Play Silent Hunter 5 Offline! > Pictorial

With a complete reinstall/registry clean done should U-play also be uninstalled/re-installed

No this is not necessary as Uplay already recognizes your game and account.

Remember
Post #5 Update SH5 From v1.0.5.0 To v1.2.0 Immediately After Installing