I would say yes. First off the Mk.48 is designed to break the ships keel by exploding under it. Second the Mk.48 has almost double the warhead then the Exocet. But don't take my word for it.
Here is a video of the RAN sub hitting a RAN destroyer with a Mk.48
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Ultima ratio regum. (The final argument of kings)
- Inscription on french cannons, on order of Louis XIV

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