Was it "mixed sample rates", Lt commander lare, or bit-depth? Windows XP didn't care, but starting with Vista, Windows and its DRM "lock" the audio stream, such that if you have an older game that didn't re-sample audio and left it to Windows, it would all work only if all the audio was of the same sample rate and bit-depth, such as 44.1kHz @ 16-bits, and if you had the computer set to that same rate. That kind of stuff gets real frustrating if you're going from Games at 44.1kHz to a movie at 48kHz, and you're using older software (like SH4)...
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