Thanks for the tips, guys. Played for a couple nights and no savegame issues beyond what is apparently the well-known crew management CTD.
The fatigue thing is making me prematurely grey though; wallowing around in the swell at 0 knots while waiting for my swabbies to rest up enough to either a) get the engines going or b) load a fish in the tubes so I can finish off the target (they are too fagged out to do both) is making me crazy. I'm going to restart the career using the NYMG 24-hour fatigue model and the other anti-savegame corruption ideas I've picked up.
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