Myself, no. I quit using my Win10 just before they released it, and had changed all sorts of stuff in the OS. However, are you running the game "as Administrator"? Are you using the Windows "Compatibility" stuff? How about "Disable display scaling on high DPI settings"? All of that is accessible from right-clicking on the SH4.exe file and choosing "Properties" at the bottom of the context-sensitive menu. Click on the "Compatibility" tab, and experiment.
Also, are you using the SH4.exe to start the game, or is your shortcut (if you're using one) pointing at "gu.exe", which is the "Game Updater", and hasn't been an operational part of the Ubisoft web site for quite a while. It might well give you an error like what you're experiencing...
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