We might have to have RR check if he's got the latest in MultiSH4 and LAA in his utility... JSGME should be v2.6. I always "install" it in the game's main folder of each install, and I will still double-check myself when enabling and deactivating mods, that I'm in the correct folder. MultiSH4 I think is v1.5 - maybe... When using LAA, be sure the SH4.exe file is not write protected, which it is when the game is first installed. Right-click on the exe file, choose Properties from the bottom of the list, and on that little window, look on the "General" tab for the "Attributes: Read only" tick box, and be sure it's empty, so that LAA can write to the file. The newest version of LAA has a nicer interface that is much more informative. Be sure and read through
CapnScurvy's Windows10; Large Address Aware; SH4 Install write-up. The jury is out on whether JSGME benefits from using LAA...