I got Windows 7 and I remember having trouble trying to get SH3 running after getting the 'Can not initialize 3D Engine' issue. And at the same time I tried to get it running in widescreen resolution. What solved it for me that I changed the Screen Refresh Rate to 60 Hertz in Moniter Setting under Control Panel. There probably has to be something similar to that in Windows 10.
For me its under Control Panel>Personalization>Display>Adjust Resolution then Advanced settings then the Moniter Tab.
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