So does the game crash when it is at the loading screen of a mission/career (like maybe shortly before the loading bar is full, at 100%?) or does it crash immediately once you hit the check mark button via commander?
Basically, does the game load up at all?
Edit:
The instructions say that you're supposed to install the mod on a fresh vanilla installation of SH3. You've said earlier that sh3 vanilla worked with win10? Depending on how far you went with your testing the LSH installation maybe failed because of that? Who knows
I would wipe everything sh3 related completely and try again, tbh. I was trying to squeeze a lot of mods into LSH which weren't made for it and even after getting rid of them it wouldn't stop the game from crashing.. I bet I installed sh3 and LSH like 10 times before I could play it the way I want it, haha..