There is one potential solution in the pipeline in regards to drone strikes.
ARSS
https://en.wikipedia.org/wiki/Autono..._Sniper_System
Much less likelihood of collateral damage, although there's still the problem of them hiding in underground places and buildings, but a drone can be on station 24/7 if you rotate them right and unless they build tunnels under the house then they'll have to come out sometime and then pop.

Equally you have to look at the bullet speed and calibre since once it has hit the target in the head...it might well keep going and hit a small child behind him. So timing and location is everything.
But it's a vast improvement over dropping a Hellfire into a marketplace or a wedding.