I haven't this situation in my rig....if I change difficulty settings the game keep the new values....
Try to check if the SH3 DATA folder allow to modify the files....
Otherwise I can only suggest to try look at the installing guide quoted above and try to reinstall the game....I do as it until point 7 but I don't install the 4gb patch and the HiRes fix....
I suggest you to start campaign only when the game is working flawless....
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