Playing the game is usually not the problem. Modding it is usually frowned upon by Vista, 7 and 8 if it is installed into the default path, AND you are not of the administrator user-type. As Steam versions are usually hidden in there, they also seem to need some special steps to work around access rights.
Also making screenshots in the game that get stored in the Program Files (something) path could throw a curveball, as User Account Control can protest when this happens. Other than that, playing should work out of the box.
Choosing a different install path that is not in the Program Files (or god have mercy on those who considered c:\Windows) avoids all that.
For installing and patching you always need administrator rights. No way around that, but is done only a few times. Since one of the latest JSGME versions you sadly also need to run as an administrator. A different install path doesn't change anything in that.
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