It all depends on who the Republicans put up against her. If they continue putting up dunderheads, she can be elected. There are too many voters who find themselves not voting for a candidate but voting against a candidate.
If the GOP were to put up a truly moderate conservative, distanced from the Tea party and the religious nutters, the GOP could sweep the elections.
When will the parties realize that the majority of the people want moderation in their government? Extremists from either end are equally bad for this country in my opinion.