No it can not run on OSx. Best way to play is to put a windows partition on.
Depending on how old/what model your mac is it should play. I have SH3 working with MEP4.3 and several other heavy mods on my mid 2012 model macbook pro 13".
I will not bore everyone with tech details but Ubi would have to release the SDK for SH3 for there to be any other OS type compatibility to come out.
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