Bad or incompatible mods usually cause game crashes, not corrupted saves.
Call me Johnny One-Note, but I still think 99% of these corrupted saves are hardware problems - bad disk sectors, so run checkdisk - or fragmented files - run defrag.
Other option, I'm still chugging along with XP, never tried Vista or anything later, could the common denominator be people who don't know how to disable UAC? From what I've read (again no first hand experience) Microsoft decided to protect users from themselves by using a "virtual folder" which doesn't actually make any changes to the original files, so when you exit any files that would have been changed or overwritten in XP have been "protected" from user changes.
In my opinion the reason UAC was invented was to stop office drones from screwing up their workstations, costing the company money for techs to unscrew the software constantly. So if it's your own personal computer and you're the only one who uses it AND you play games which require changes to files, turn the blasted thing off.
http://windows.microsoft.com/en-us/w...#1TC=windows-7