Where does it say that it "flew 2000 km with an open mainframe"? And how does a single 2-ft square panel missing become "panels"?
It is clearly a maintenance hatch in the unpressurised underwing fairing. Not good to lose it, obviously, but unlikely to be safety critical. As for the cause, I see no reason to assume any sort of design fault at this stage - and people can fail to close hatches etc properly on any manufacturers aircraft.
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