Are you running 32-bit or 64-bit Win7? AFAIK, all versions of the 4GB patch are incompatible with 32-bit Win7.
You have Commander installed. Do you have the .cfg files for GWX3 installed also?
Have you ever, ever, EVER activated or deactivated any mod without rolling back Commander? (This is a really bad thing to do, and is guaranteed to cause problems.)
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