It shouldnt afaik. You could test that tho by disabling all mods, and then running sh5 .. if no CTD's happen, it's logically somewhere in the mods, their order, or the absence of prerequirements.
By doing it the way I describe, (and which I copied and adapted from
here) you can easily deactivate it, update other mods, recopy needed files, repatch without being unable to revert to prepatched version without storing backup files in your own locations. Keeps stuff together nice and ordered
