My experience has been that SH4 is the most stable of the three games (SH3, SH4, SH5). SH5 is so graphics-intensive that I am likely having problems due to the fact that I have at best a B grade processor, maybe B-. (certainly not top end.) SH3, especially heavily modded, requires careful handling, multi-saving, and a philosophical attitude when my last save goes pear-shape. SH4, on the other hand, seems pretty robust - by comparison. Of course, SH4 also lacks the sophisticated .exe patching of SH3 and SH5, and the load-time file modification of SH3 Commander. Much more potential for things to get corrupted there.
@c13Garrison: In-game CTDs in SH4, as opposed to corrupted saves, are something I don't have much experience with. Please post your mod list and operating environment (HW and OS), and maybe someone will spot a possible source of problems.
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