There was an episode in "House" dealing with a brain-eating amoeba, it was a double-episode entitled "Euphoria". There they said it also was an extremely painful infection, because the drugs fighting pain can no longer become active in the brain. It was an absolutely frightening story they told, a real horror tale. Foreman got infested from a patient who died by these amoeba, in terrible pain that made him literally mad.
The amoebas then got killed by exposing Foreman to either Legionell or a drug against Legionellas or both.
Back then I thought: nightmare scenario: maximum pain - and the brain structures allowing drugs to switch pain off - destroyed.
German press reported about a dramatic increase of such amoebas in American lakes in 2011, and since then. Ir seems they are spreading, probably due to warming up of potential water reservoires where such amoebas can live.
There are things out there you do not wish even your worst enemy or the most disgusting scum on Earth.
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If you feel nuts, consult an expert.
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