If your organization relies on consultant ware, like most large organizations, IE is the only way to go.
IE editions are supported for nearly 10 years, a new version comes out every few years. A new version of firefox comes out every 6 weeks, and the previous version is no longer supported (there are a few LTS versions though, but they have their own problems).
If I am going to spend millions on hiring people to write me software, the users will probably end up using IE instead of any other browser. An example would be the software we used at my school, it was designed for IE 6 and Netscape 4. Netscape 4 was abandoned years ago, while IE 6 is still supported.
PS: I'm pretty sure Opera is going to share a rendering and javascript engine with Chrome, thus, a lot of common vulnerabilities will be shared between both browsers. And really, just like what my security textbook says, security through obscurity is no security at all!
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