Welcome back PULSEOX.
When you do the install it, the installation software will check your computer and tell you if it will run SH5. If you have an i7 or equivalent AMD CPU over 3.0GZ, a 64bit OS, and more than 8GBs of DDR3 RAM you should be good to go. Oldest GFX card that will run with SH5 is a GF 8800GT or equivalent AMD card.
I'm running it on XP Home, 2.82 i5 cpu, 4GBs of DDR3 Ram (can't use all 4GBs with a 32bit system), and a Zotac GF 8800GT 1GB GFX card. I'm at the low end but it still runs ok... so far. The amount of mods you install can slow SH5 down too.