For sure acceleration is a game killer
I'm using 53 mods in my list, and best is to NEVER pass over X512.
X256 is perfect in almost all situations on my rig, and i use 512 for open quiet seas.
Furthermore, acceleration is a mess with sounds mods.
Best is to let the sound animations play before accelerating! Otherwise strange things may happen.
I noticed boat smoke doesn't like acceleration too. Accelerating for a moment and back ingame, smoke is shifted away from chimney...
Best is to follow Sober's advice, and set game to not pass over X256/X512