I suck at math, so I do semi-auto: Targetting set for Manual, WE Assistance on. I also use the Assisted Plotting Mod, in which nothing appears on the chart except the ship you are locked onto.
http://www.subsim.com/radioroom/show...9&postcount=10
I don't use any of the GUI mods, preferring an uncluttered screen instead. I use FLB_Sales' Simfeeling 6-Dials mod.
http://www.subsim.com/radioroom/show...74&postcount=5