As "calling tech support as it sounds", just restart the computer.
I'm playing SH3 + GWX + mod soup, using the steam version through SH3 commander with no problems at all. I do get that error once in a while after I close SH3 and reopen it, but the load continues and I can play. It thinks a second instance is trying to load, choices are either restart or go pick out the offending programs in task manager.
FYI: Turn off autoupdate in Steam.
Biggest issue I have is that sometimes I have problems getting a change to stick, but I think that is me, not SH3 and not Steam.
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