I would caution against changing text files. Config files (.cfg) are text files and IIRC, I have had problems when changing those out of port. Best to limit changes to sound files (.ogg or .wav) when out of port. These can be changed anytime.
I find that the fewer mod changes I make when out of port, the less likely I am to get strange in-game behavior.
There is at least one mod (RUIM) which can only be installed succesfuly at the start of a career. (Please don't ask me how I know this. :-P)
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