@Skybird:
There were issues with a previous version of F-Secure but they seemed to have been ironed out with the latest version. I experience no slowdown at all with the latest version and as some have mentioned I can turn it off and on as I please. You could always give it a try, think they are now doing a free trial for potential customers.
My brother use ESET NOD32 and is very happy with them, didn't see that in your list.
Ones I stay away from (after personal experience)
Norton
AVG
McAfee
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