This was reported by Heibges
Fix for CTD at Main Loading Screen.
The game ran flawlessly for about 60hrsover 5 days before I encountered this bug. I had 6 Careers.
The Game Loaded, Ubi Logo Screen appeared, Intro Video played, and game CTD halfway through Main Loading Screen.
Workaround:
Cut and Paste all your carreers from Careers folder to Desktop. Cut and Paste all your careers from your desktop back to Careers folder.
Game now loads normally.
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look in your documents folder for the SH3 folder
not really sure what is going on , just trying to point you in a direction. Check out the SH3 tech and troubleshooting thread.
http://www.subsim.com/phpBB/viewtopic.php?t=30321