I had problems with this mod when i first installed it. It'd either CTD on start up or CTD as soon as i came into the game.
Then i installed the 4 gb patch and haven't had any problems with it at all. Start up takes a little longer but once in game it's as fluid and smooth as it should be.
You of course have to have 4 gig of ram if you're going to install the 4 gb patch...
It's a resource heavy mod so lesser spec machines might have a problem with it.