Fallout New York. Not just the city, but a representation of the entire state/area, kinda like how New Vegas simulates nearly the entire SW.
It would be cool to see the mangled bridges. Maybe even find a way to include vehicles.
You would think logically it would have been a priority target for nuclear destruction by the Chinese. I am not just saying that because I want to see a bridge I cross a few times a week under the duress of heavy traffic mangled into nuclear oblivion.
Hopefully I will run by that jerks skeleton in game, who rear ended me, then faded back in traffic a few weeks ago, maybe launch a few fatmans at his car.