Not sure if that's what's causing it, but I'm fairly sure that you need to enable FX
before NewUIs.
Also, sometimes mod mixing can leave bits and pieces behind even after you disable the previous setup, which would necessitate a reinstall of SH5, but I wouldn't go to that extreme just yet.
For what it's worth, here's my somewhat modest mod soup and it's stable as a rock. Check the mods you're using and see which order they appear in my list. (Oh, and some of them have been modified slightly by me, so if the names don't match the official versions, just ask away).
Code:
Generic Mod Enabler - v2.6.0.157
[C:\Ubisoft\Silent Hunter 5\MODS]
SH5 Patch and Gramophone Shuffler
Accurate German Flags
RemoveLogoIntroTheDarkWraith
sobers green spinning thing SH5
No Damn Bubbles, No Damn Halo Mod
Dynamic Environment SH5 Basemod (normal ) V2.1
Dynamic Environment SH5 Waves (normal version) V2.1
Dynamic Environment SH5 BrighterNights V2.1
Dynamic Environment SH5 Sounds V2.1
Dynamic Environment SH5 v 2.1 - Skycolor Hotfix #1
No magic skills v1.5 MCCD compatible
MightyFine Crew Mod 1.2.1 Alt faces
MFCM 1.2.1 OPTIONAL crash_dive workaround
MCCD_1.04_MFCM_1.2.1_compatible
Speech fixes and additions (german version)
SteelViking's Interior Mod V1.2
SteelViking's Interior Mod V1.2.2 Patch
Fuel Gauge WoGaDi_SteelViking's Interior
Stormys DBSM SH5 v1.3 Basemod (no beards)
Stormys DBSM SH5 v1.3 additional crew sounds beta6 and hotfix (no beards)
sobers best ever fog V9 SH5
Small_trees_SH5_V1
sobers 3D deck spray mod V7
Window_Lights_Redone_V1
NOZAURIO'S SKIN (Standar No Emblem) v-1.0.0
Pascal-sh5-Crew-Uniforms. 12.2011
FX_Update_0_0_19_ByTheDarkWraith
IRAI_0_0_30_ByTheDarkWraith (for Sober Fog)
IRAI_upgrade_to_v_0_0_31
NewUIs_TDC_6_9_0_ByTheDarkWraith
Manos Scopes-patch for 16x9
Critical hits 1.1 Torpedos
KZS Hull wetness for U-Boats + co tower and deck_revised_by_TheDarkWraith
OPEN HORIZONS II_base v1.8
OPEN HORIZONS II_enviro v1.8
OHIIv1.8 Base+environ patch1
OH II Minefield map for TDWs Ui
Trevally Tutorials - All v0.2 (for TDW UI)
Trevally Automated Scripts v0.6
Trevally Harbour & Kiel Canal Pilot v2.8
Grossdeutscher Rundfunk
sobers NO water drops V1
smaller flags for Warships 1_0b
sobers hud sounds V1 SH5
Change days in bunker
stoianm colored exterior mod v2 (low color)