a good practice is to double save your saved games so you have a baxckup if the main save gets corrupted. i will often keep a save point from last port or something like that so i only lose a short period of game play if something happens. this wouldnt help you if the issue was mod related but it is still a good habit to do.
often saving before some game action completes such as a ship sinking, being recorded as sunk, then the time it takes before it vanishes, or reaching the memory limits of your computer can screw things up with game saves but many times its hard to really know why these corruptions happen
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