With a computer of 2007 vintage that can run the game, no. I ran with an Asus A8N-SLI Deluxe, Athlon single core slow as Hades processor (3700+), an EVGA 7600GT graphics card and two GB of memory, the minimum that Windows XP liked to run on. This was truly the minimum configuration that SH4 would run on, much worse than any off the shelf computer today.
No save problems. With each of three successive total rebuilds the story is the same. No save problems under any circumstances. I have saved in a harbor, under attack, submerged with a torpedo halfway to the target, reloaded and watched the torpedo strike. If SH4 was going to crash I would have destroyed it.
Conclusion: it is way too easy to have a problem and blame it on something completely coincidental. For thousands of years everybody knew that stomach ulcers were caused by stress and the fix was a super-mild disgusting diet and surgery. Then a doctor who wasn't even a proper researcher discovered the h. pylori bacteria and attributed ulcers to it.
Suddenly the world changed and ulcers were the product of an infection treatable with an antibiotics regime. My wife had one cured that way. All that torture (or most of it anyway) was completely unnecessary and based on a false cause and effect.
Same with SH4. The problem is elsewhere. An effect is not a cause. Separating one from the other is sometimes difficult.
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