That depends on your vision of vampires... perhaps a Anne Rice vampire would indeed get weak with lack of blood.. However if you take a White Wolf vampire they enter a state of blood lust and do actually get stronger, although they lose what little humanity they have almost entering a sort of feral werewolf state turning on friend and foe, which is loosely seen in Elder Scrolls vampires as the stronger you get the more the people turn on you and dislike you even though you never really lose control of your character.
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