Let's see...
According to documents released after his death and accounts by reputable persons who were privy to the White House during the "Camelot" years, at the time of his death, Kennedy was actively pusuing an end to U.S. involvement in Vietnam; was moving forward on a plan to either rein in or eliminate the Federal Reserve Bank system; moving to end CIA infiltration of non-political humanitarian efforts such as the Peace Corps.; broadening the efforts of the U.S. Attorney-General, Robert Kennedy, to clamp down on organized crime and its links to the labor unions; pushing for accountability from the FBI (and J. Edgar Hoover); actively endorsing technological advances; attempting to break the "unholy alliance" of the "military-industrial complex"; and, had successfully faced down the USSR...
Not to shabby for less than three years efforts...