Guys, there are many posts and threads on this forum to help with this. Here is a recap of some of the basics I applied to avoid crashes:
1. Do not load the game to the default {Program Files) directory if you run Win7- instead create a new directory in your C: drive (I use "Games") and make a clean install to that one (v1.4+Uboats_TMO, etc.) it to that one.
2. If you do have to reinstall, be sure and delete all files from the previous install - there are SH4 files in your "My Documents" folder that you may not have noticed.
3. If you have more than 2 GB of RAM (SH4-TMO2.2-RSRD are memory hogs) run the program from the Downloads section that increases the game's use of Ram from 2 GB to 4GB - that was magic for me.
Try those and let us know; otherwise, continue to research problems and solutions in the forum. Good luck!