With any of the supermods the mantra is "keep it simple." Stacking other mods on top of them, unless specifically certified by the author(s) of the supermod can and most times will cause bad effects, which can include CTDs. Unless you know modding very well, I'd run 'em naked.
TMO 2.2 is very stable, and I've had no CTDs. If you are having them you're doing something wrong. It doesn't take much to ruin a good thing. Stacking mods is first, last and center of what causes stability problems.
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