SH4 has no use for Adobe Reader. Atleast, it doesn't force you to read the manual while playing the game. (sarcasm: a fat lot of good that thing will do to you anyway) So this can't be the reason for the malfunction. Please state where you got this information from.
A crash during loading the game probably has more to do with mod incompatibility or saving the game (at an earlier time) while in a risky game state known to cause bugs. (which I cannot suggest at the moment)
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