I will say that it has much lower range,is less maneuverable,and has a much lower payload and would often have to carry some load out externally meaning that its stealth gets compromised half the time thanks to that.
Not going to get into a discussion about it beyond that as you obviously have posted nothing else in this thread and are clearly a big fan of the F-35 and are o the hunt so to speak not taking that bait just because you are a fan boy don't assume that others are
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I am not saying stick to older technology I am saying develop newer better airframes not ones that only gain one thing at the cost of others when one can develop something that is much less of a compromise.