I have been playing this game for better than 3 years and maybe had 5 or 6 CTDs and they were a long time ago so the game can be very stable.
I have run many mods in many different combinations and very seldom have even a bad save. I save any time' any place and under any circumstances with no problems. Only thing I do when saving is go to the Nav map and pause the game before I save.
Just my own personal option but it seems to me that most CTDs and bad saves are either conflicts with other programs or are hardware related.
Maybe post your system specs and some of the sharper folks can find the problem. Hate to loose a fellow submariner. There is a war on fella and we need all the help we can get.
Magic