Always a tough question, tbh there is no definitive answer.
And certainly no one correct answer. Why?
Because everyone plays a little differently, realism levels, immersion levels, voice recognition, point and click style, auto (scripted) style gameplay, there are so many ways you can play this game.
In my opinion, what i suggest to you is that you alone try different mods and see if the mods adapt to your style of play.
There are many wonderful mods here, all have different roles to play, all are wonderful in their own way.
New UI's TDC by TDW is a must imo, so is Real Environment Revision.
These 2 alone stand out as the jewels in the crown.
All i can say is:
Experiment, experiment, experiment!
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