Some people report that they can save within range of other units and then reload the save without any problems... but personally I wouldn't risk it.
If it's possible to leave your computer on, you can always just pause the game where it is and come back to it later and unpause it and keep playing. The only danger that I can see there is if Windows or some background program decides to do an auto-update and then reboot your system afterwards, if you're set up to allow that.
Like I said, though, some people don't seem to get bitten by the savegame bug in that situation so it's up to you.
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