How old is your pc? Mine is five years old; and I can run GWX + the High resolution mod and MEP V3 (which is a mod that improves the ingame environment). I haven't tried Flakman's Interior Mod yet; that one seems to be the heaviest on your computer.
By the way; if you're getting GWX then be sure to also activate the GWX-Lite Harbor Traffic mod (it's part of GWX so no need to download it seperately, just activate through JSGME) It decreases the number of ships rendered in the harbors which will make sh3 run more smoothly.
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