The weather in the Med is generally more agreeable; though by the time Salamis opens up (several months before La Spezia does if you want to transfer as soon as one opens) airplanes have already started to become a real pest. You'll get better sailing weather but there's few dead spots for air coverage in the med (at least anywhere where you'll find any merchants or TF's) forcing you to spend more time submerged waiting for nightfall.
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