a game saved with mods will give you a CTD if you load it without them or after the mods are removed because the game cant find what its looking for and crashes as a result.
in a few special cases the mod may have made minor enough or unrelated changes (such as changing what already existed so the game CAN find what its looking for) so the game works but when you get to a spot where the missing content is it will crash.
as a rule expect a CTD if a save game is used unless all mods being used at the time of the save are installed first AND installed in the exact same order as they were when the game was saved is also usually required
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